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CS-W001157 4
Total: USD 88.00

(S)-3-(tert-Butyl)-4-(2-methoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole

  • CAS No. 2448646-14-6

  • Cat. No. CS-0092280
  • Purity≥95%
  • MDL No.MFCD32641178

*For research and further manufacturing use only, not for direct human use.

(S)-3-(tert-Butyl)-4-(2-methoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole|CS-0092280

Structure of 2448646-14-6

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General Information

  • CAS No. 2448646-14-6
  • Cat. No. CS-0092280
  • Purity ≥95%
  • MDL No. MFCD32641178
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₁O₂P
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COC1=CC=CC=C1C2=C([P@](C(C)(C)C)CO3)C3=CC=C2

Description

This chiral phosphole integrates a tert-butyl group and a 2-methoxyphenyl moiety, delivering enhanced steric bulk and electron-rich character. The dihydrooxaphosphole core provides a stable, bench-ready scaffold for asymmetric synthesis and transition-metal catalysis.

Application

(S)-3-(tert-Butyl)-4-(2-methoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole serves as a bench-stable, chiral phosphorus building block enabling stereoselective transformations in asymmetric synthesis. Its ortho-methoxyphenyl moiety enhances reactivity in Pd-catalyzed cross-coupling processes, while the tert-butyl group provides steric bulk and structural integrity. Functions effectively in ligand design and heterocycle construction, offering predictable regiochemistry and compatibility with standard purification protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   4.6178
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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