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CS-W001157 4
Total: USD 88.00

2,3-Dihydro-1H-inden-5-amine

  • CAS No. 24425-40-9

  • Cat. No. CS-0088459
  • Purity≥98%
  • MDL No.MFCD00003803

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydro-1H-inden-5-amine|CS-0088459

Structure of 24425-40-9

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General Information

  • CAS No. 24425-40-9
  • Cat. No. CS-0088459
  • Purity ≥98%
  • MDL No. MFCD00003803
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁N
  • Molecular Weight 133.19
  • Synonym(s) 5-Indanamine
  • SMILES NC1=CC=C2C(CCC2)=C1

Description

5-Aminoindan was used in the synthesis of ligand 18/18 (2-(5-aminoindan)-6-(5-aminoindan)-4-chloro-s-triazine).

Application

2,3-Dihydro-1H-inden-5-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amine functionalization. Its bench-stable nature and compatibility with common coupling reactions facilitate efficient synthesis of indole-derived scaffolds. The molecule functions as a key intermediate in the development of CNS-targeted compounds and other pharmacologically relevant architectures, offering predictable reactivity and ease of purification in multi-step sequences.

Synthesis

  • Route1
    • tert-Butyl (2,3-dihydro-1H-inden-5-yl)carbamate|CS-0730644
      695231-56-2
    • ~99%
    • In-stock
      2,3-Dihydro-1H-inden-5-amine|CS-0088459
      24425-40-9

    References

    • Tom, Norma J.; Simon, Wendy M.; Frost, Heather N.; Ewing, Marcus Tetrahedron Letters, 2004 , vol. 45, # 5 p. 905 - 906
  • Route2
    • 5-nitro-2,3-dihydro-1H-indene|CS-0033867
      7436-07-9
    • ~%
    • In-stock
      2,3-Dihydro-1H-inden-5-amine|CS-0088459
      24425-40-9

    References

    • Monatshefte fuer Chemie, , vol. 105, p. 1362 - 1373
  • Route3

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 519 - 523

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.7575
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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