Thalidomide 4-chloro

Name: Thalidomide 4-chloro
Brand: ChemScene
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CAS No. 244057-36-1
Cat. No. CS-0527522
Purity≥96%
MDL No.MFCD30188071

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 244057-36-1

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General Information

CAS No. 244057-36-1
Cat. No. CS-0527522
Purity ≥96%
MDL No. MFCD30188071
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉ClN₂O₄
Molecular Weight 292.68
Synonym(s) None
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3Cl)=O

Description

Thalidomide 4-chloro integrates a chlorinated aryl moiety at the 4-position, enhancing electronic and steric profile for targeted protein engagement. This derivative maintains bench-stable handling characteristics while offering improved metabolic resilience in synthetic biology workflows.

Application

Thalidomide 4-chloro serves as a privileged scaffold in medicinal chemistry, enabling targeted modulation of protein-protein interactions. Its electron-withdrawing chlorine substituent enhances metabolic stability and fine-tunes binding affinity within the cereblon E3 ligase complex. The molecule functions as a robust building block for immunomodulatory drug discovery, offering predictable reactivity in standard coupling and functionalization protocols. Bench-stable and amenable to purification via standard chromatographic methods, it supports scalable synthesis of analogs with defined biological profiles.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

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Computational Chemistry Data

TPSA 83.55
LogP 0.7154
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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Thalidomide 4-chloro

CAS No. 244057-36-1

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