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CS-W001157 4
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3-(5-Bromo-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

  • CAS No. 2438240-68-5

  • Cat. No. CS-0567209
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(5-Bromo-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione|CS-0567209

Structure of 2438240-68-5

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General Information

  • CAS No. 2438240-68-5
  • Cat. No. CS-0567209
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀BrFN₂O₃
  • Molecular Weight 341.13
  • Synonym(s) None
  • SMILES O=C(C(N(CC1=C2C(F)=CC(Br)=C1)C2=O)CC3)NC3=O

Description

This piperidine-2,6-dione scaffold features a 5-bromo-7-fluoro-1-oxoisoindolinyl group that imparts electron-withdrawing character and enhanced metabolic stability. The fused ring system enables robust integration into bioactive scaffolds, particularly in kinase inhibitor development. Bench-stable and compatible with standard coupling protocols, this compound serves as a key building block for medicinal chemistry campaigns requiring halogenated, sterically defined heterocycles.

Application

3-(5-Bromo-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile building block for isoindolinone-based scaffolds in medicinal chemistry. Its bromo and fluoro substituents enable downstream cross-coupling reactions, while the diketone functionality supports enolization and nucleophilic addition. The compound exhibits bench stability and facilitates efficient functional group manipulation, making it well-suited for parallel synthesis campaigns targeting bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   0.765
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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