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CS-W001157 4
Total: USD 88.00

N,N-Dimethylnaphthalen-2-amine

  • CAS No. 2436-85-3

  • Cat. No. CS-0181804
  • Purity≥98%
  • MDL No.MFCD00059550

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylnaphthalen-2-amine|CS-0181804

Structure of 2436-85-3

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General Information

  • CAS No. 2436-85-3
  • Cat. No. CS-0181804
  • Purity ≥98%
  • MDL No. MFCD00059550
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃N
  • Molecular Weight 171.24
  • Synonym(s) 2-Dimethylaminonaphthalene
  • SMILES CN(C)C1=CC=C2C=CC=CC2=C1

Description

N,N-Dimethylnaphthalen-2-amine is a bench-stable, electron-rich amine featuring a para-dimethylamino group on a naphthalene core. This configuration enhances its utility in transition-metal-catalyzed cross-coupling reactions and as a ligand in palladium-mediated transformations. The compound exhibits good solubility in organic solvents and maintains reactivity under standard conditions.

Application

N,N-Dimethylnaphthalen-2-amine serves as a robust electron-rich aryl amine scaffold, enabling efficient palladium-catalyzed cross-coupling reactions. Its dimethylamino group enhances nucleophilicity and stabilizes intermediates in Buchwald–Hartwig amination protocols. The compound exhibits excellent bench stability, facilitates straightforward purification via silica gel chromatography, and functions as a versatile building block for functionalized heterocycles and advanced pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.9058
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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