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CS-W001157 4
Total: USD 88.00

KT-474

  • CAS No. 2432994-31-3

  • Cat. No. CS-0374973
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

KT-474|CS-0374973

Structure of 2432994-31-3

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General Information

  • CAS No. 2432994-31-3
  • Cat. No. CS-0374973
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₄H₄₉F₂N₁₁O₆
  • Molecular Weight 865.93
  • Synonym(s) KYM-001; PROTAC IRAK4 degrader-7
  • SMILES O=C1N(C(CCC2=O)C(N2)=O)C3=CC=CC(C#CCOC(CC4)CCN4C[C@H]5CC[C@@](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@@H](CO9)C[C@@H]9C8)C=C%10)N%10N=C7)=O)([H])CC5)=C3N1C

Description

KT-474 is a bench-stable, electron-deficient heterocycle designed for efficient coupling in late-stage functionalization. This nitrogen-containing scaffold integrates readily into complex molecular architectures, offering high compatibility with transition-metal catalysis and enhanced reactivity under mild conditions.

Application

KT-474 serves as a versatile building block for constructing nitrogen-containing heterocycles, particularly pyrrolidines and piperidines, via reductive amination or cyclization protocols. Its functional group tolerance enables straightforward incorporation into complex molecular architectures, while its bench stability and ease of purification support efficient synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   175.15
  • LogP   3.9883
  • H_Acceptors   15
  • H_Donors   2
  • Rotatable_Bonds   10

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