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CS-W001157 4
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6-Aminohexanenitrile

  • CAS No. 2432-74-8

  • Cat. No. CS-0147655
  • Purity≥98%
  • MDL No.MFCD00009822

*For research and further manufacturing use only, not for direct human use.

6-Aminohexanenitrile|CS-0147655

Structure of 2432-74-8

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General Information

  • CAS No. 2432-74-8
  • Cat. No. CS-0147655
  • Purity ≥98%
  • MDL No. MFCD00009822
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂N₂
  • Molecular Weight 112.18
  • Synonym(s) None
  • SMILES N#CCCCCCN

Description

6-Aminohexanenitrile features a terminal amine and nitrile group separated by a six-carbon chain, enabling dual functionalization in polymer synthesis and bioconjugation. This bifunctional scaffold integrates readily into peptide backbones and supports efficient derivatization under mild conditions.

Application

6-Aminohexanenitrile serves as a versatile bifunctional building block for the synthesis of cyclic and acyclic amides, lactams, and polyamides. Its nitrile group enables nucleophilic addition and conversion to carboxylic acid derivatives, while the primary amine facilitates coupling reactions and derivatization. The molecule exhibits good bench stability and is compatible with standard protecting group strategies, making it valuable in peptide-like scaffold construction and polymer chemistry workflows.

Synthesis

  • Route1
    • null|null
      185350-62-3
    • ~0%
    • In-stock
      Azepan-2-one|CS-W011258
      105-60-2
    • In-stock
      6-Aminohexanenitrile|CS-0147655
      2432-74-8
    • Ethyl 6-aminohexanoate|CS-0299112
      371-34-6

    References

    • BASF Aktiengesellschaft Patent: US6683177 B1, 2004 ; Location in patent: Page column 5 ;
  • Route2
    • null|null
      111-69-3
    • ~76%
    • In-stock
      6-Aminohexanenitrile|CS-0147655
      2432-74-8

    References

    • Medina, Francisco; Salagre, Pilar; Sueiras, Jesus-Eduardo; Fierro, Jose-Luis-Garcia Journal of the Chemical Society, Faraday Transactions, 1993 , vol. 89, # 18 p. 3507 - 3512
  • Route3
    • null|null
      89488-73-3
    • ~65%
    • In-stock
      6-Aminohexanenitrile|CS-0147655
      2432-74-8

    References

    • Luo, Liang; Wilhelm, Christopher; Sun, Aiwu; Grey, Clare P.; Lauher, Joseph W.; Goroff, Nancy S. Journal of the American Chemical Society, 2008 , vol. 130, # 24 p. 7702 - 7709

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.81
  • LogP   1.02908
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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