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CS-W001157 4
Total: USD 88.00

2-(4-Fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 243145-83-7

  • Cat. No. CS-W019272
  • Purity≥95%
  • MDL No.MFCD10698519
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-W019272

Structure of 243145-83-7

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Description

This boronate reagent features a 4-fluorobenzyl group integrated into a stable, tetramethyl-substituted dioxaborolane scaffold. The electron-withdrawing fluorine enhances electrophilicity at the aromatic ring, facilitating efficient cross-coupling reactions. Bench-stable and moisture-tolerant, it streamlines the incorporation of fluorinated aryl motifs in synthetic sequences.

Application

2-(4-Fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. Its tetramethyl-substituted dioxaborolane moiety enhances air and moisture stability while enabling efficient coupling with aryl halides and triflates. The 4-fluorobenzyl group provides a readily functionalizable handle for downstream derivatization in medicinal chemistry and materials synthesis.

General Information

  • CAS No. 243145-83-7
  • Cat. No. CS-W019272
  • Purity ≥95%
  • MDL No. MFCD10698519
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈BFO₂
  • Molecular Weight 236.09
  • Synonym(s) 4-Fluorobenzylboronic acid pinacol ester
  • SMILES CC1(C)OB(CC2=CC=C(F)C=C2)OC1(C)C

Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.9996
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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