2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid

Name: 2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 242475-26-9
Cat. No. CS-0042055
Purity≥97%
MDL No.MFCD02662404

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid|CS-0042055

Structure of 242475-26-9

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General Information

CAS No. 242475-26-9
Cat. No. CS-0042055
Purity ≥97%
MDL No. MFCD02662404
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₈F₃NO₂
Molecular Weight None
Synonym(s) None
SMILES O=C(O)C(N)C1=CC=CC(C(F)(F)F)=C1

Description

2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid delivers a robust, electron-deficient aryl scaffold paired with a pendant amino group, enabling direct incorporation into peptide-like architectures. This bench-stable derivative supports synthetic access to bioactive molecules under standard conditions.

Application

2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide-like scaffolds. Its trifluoromethyl aryl group imparts enhanced metabolic stability and lipophilicity, while the α-amino carboxylic acid functionality supports diverse transformations including coupling reactions, cyclizations, and derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in drug discovery.

Synthesis

Route1
- 82425-18-1
- ~%
- In-stock
  
  242475-26-9
References
- Journal of Medicinal Chemistry, , vol. 36, # 3 p. 314 - 319
Route2
- In-stock
  
  2338-76-3
- ~%
- In-stock
  
  242475-26-9
References
- Journal of Medicinal Chemistry, , vol. 36, # 3 p. 314 - 319

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.32
LogP 1.7898
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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2-Amino-2-(3-(trifluoromethyl)phenyl)acetic acid

CAS No. 242475-26-9

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