2,6-Difluoro-4-iodonicotinaldehyde

Name: 2,6-Difluoro-4-iodonicotinaldehyde
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CAS No. 2417489-94-0
Cat. No. CS-0378279
Purity≥97%
MDL No.MFCD34603408

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,6-Difluoro-4-iodonicotinaldehyde|CS-0378279

Structure of 2417489-94-0

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General Information

CAS No. 2417489-94-0
Cat. No. CS-0378279
Purity ≥97%
MDL No. MFCD34603408
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂F₂INO
Molecular Weight None
Synonym(s) 2,6-Difluoro-4-iodo-3-pyridinecarbaldehyde
SMILES O=CC1=C(I)C=C(F)N=C1F

Description

2,6-Difluoro-4-iodonicotinaldehyde features a highly reactive aldehyde group flanked by electron-withdrawing fluorine and iodine substituents, enhancing electrophilicity for efficient coupling in cross-coupling and bioconjugation workflows. The para-iodo substitution enables palladium-catalyzed transformations, while the ortho-fluorines improve metabolic stability and modulate electronic properties. This bench-stable reagent integrates readily into complex molecular architectures under standard conditions.

Application

2,6-Difluoro-4-iodonicotinaldehyde serves as a versatile building block for the synthesis of fluorinated heterocycles and pharmaceutical intermediates. Its aldehyde functionality enables efficient nucleophilic additions and condensation reactions, while the ortho-fluoro and para-iodo substituents facilitate subsequent cross-coupling and electrophilic functionalization. The molecule exhibits good bench stability and compatibility with standard reaction conditions, supporting its use in multi-step synthetic sequences requiring orthogonal reactivity.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 1.7769
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Difluoro-4-iodonicotinaldehyde

CAS No. 2417489-94-0

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