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Structure of 2417014-06-1
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This boronate-functionalized pyrimidine integrates readily into Suzuki-Miyaura coupling reactions under standard conditions, delivering trifluoromethyl-substituted heterocycles with high efficiency. The tetramethylborolane group ensures excellent stability and compatibility in diverse synthetic workflows.
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate group enables stable, air-tolerant handling and facilitates efficient coupling with aryl, heteroaryl, and vinyl halides under mild conditions. The trifluoromethylpyrimidine core provides a valuable pharmacophore in medicinal chemistry, offering enhanced metabolic stability and lipophilicity. This reagent functions reliably in diverse synthetic workflows, enabling rapid access to complex heterocyclic scaffolds with predictable regiochemistry and high functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: