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CS-W001157 4
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3-Chlorobenzenecarboximidamide hydrochloride

  • CAS No. 24095-60-1

  • Cat. No. CS-W020729
  • Molecule weight191.06
  • Purity≥97%
  • MDL No.MFCD00276754

*For research and further manufacturing use only, not for direct human use.

3-Chlorobenzenecarboximidamide hydrochloride|CS-W020729

Structure of 24095-60-1

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General Information

  • CAS No. 24095-60-1
  • Cat. No. CS-W020729
  • Purity ≥97%
  • MDL No. MFCD00276754
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈Cl₂N₂
  • Molecular Weight 191.06
  • Synonym(s) 3-chloro-Benzenecarboximidamide,hydrochloride
  • SMILES N=C(C1=CC(Cl)=CC=C1)N.[H]Cl

Description

3-Chlorobenzenecarboximidamide hydrochloride delivers a reactive imidamide handle tethered to an electron-deficient aryl ring, enabling efficient coupling in heterocycle synthesis. The hydrochloride salt enhances solubility and stability under standard bench conditions, facilitating straightforward handling in medicinal chemistry workflows.

Application

3-Chlorobenzenecarboximidamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of imidazole and triazole heterocycles via cyclization reactions. Its stability under standard bench conditions and compatibility with common functional groups facilitate efficient synthesis of bioactive scaffolds. The compound functions as a key intermediate in the development of targeted therapeutics, particularly in the exploration of kinase inhibitors and antimicrobial agents.

Synthesis

  • Route1
    • Ethyl 3-chlorobenzene-1-carboximidate hydrochloride|CS-0122252
      60612-87-5
    • ~66%
    • In-stock
      3-Chlorobenzenecarboximidamide hydrochloride|CS-W020729
      24095-60-1

    References

    • Sudheendran, Kavitha; Schmidt, Dietmar; Frey, Wolfgang; Conrad, Juergen; Beifuss, Uwe Tetrahedron, 2014 , vol. 70, # 8 p. 1635 - 1645
  • Route2
    • Ethyl 3-chlorobenzimidate|CS-0539561
      827-64-5
    • ~%
    • In-stock
      3-Chlorobenzenecarboximidamide hydrochloride|CS-W020729
      24095-60-1

    References

    • WO2014/66659 A1, ; Paragraph 0556 ;
  • Route3
    • null|null
      56108-07-7
    • ~%
    • In-stock
      3-Chlorobenzenecarboximidamide hydrochloride|CS-W020729
      24095-60-1

    References

    • Journal of Medicinal Chemistry, , vol. 33, # 4 p. 1230 - 1241

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.87
  • LogP   2.04587
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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