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CS-W001157 4
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Methyl 4-formyl-3-methylbenzoate

  • CAS No. 24078-24-8

  • Cat. No. CS-0450251
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 4-formyl-3-methylbenzoate|CS-0450251

Structure of 24078-24-8

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General Information

  • CAS No. 24078-24-8
  • Cat. No. CS-0450251
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₃
  • Molecular Weight 178.18
  • Synonym(s) Benzoic acid, 4-formyl-3-methyl-, methyl ester
  • SMILES CC1=CC(=CC=C1C=O)C(=O)OC

Description

Methyl 4-formyl-3-methylbenzoate features a formyl group positioned para to the ester, delivering enhanced reactivity in electrophilic coupling and cross-coupling protocols. The methyl substituent at the meta position provides steric and electronic modulation, improving solubility and stability under standard conditions. This compound serves as a key scaffold for synthesizing bioactive heterocycles and functionalized aromatic systems in medicinal chemistry and materials science.

Application

Methyl 4-formyl-3-methylbenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic scaffolds. The ortho-methyl and formyl groups provide complementary reactivity for electrophilic functionalization, Suzuki-Miyaura coupling, and oxidation/reduction sequences. Its bench-stable nature and compatibility with common protecting group strategies facilitate straightforward purification and integration into multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.59412
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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