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CS-W001157 4
Total: USD 88.00

2,3,5,6-Tetrachloropyridine

  • CAS No. 2402-79-1

  • Cat. No. CS-0128415
  • Purity≥98%
  • MDL No.MFCD00092428

*For research and further manufacturing use only, not for direct human use.

2,3,5,6-Tetrachloropyridine|CS-0128415

Structure of 2402-79-1

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General Information

  • CAS No. 2402-79-1
  • Cat. No. CS-0128415
  • Purity ≥98%
  • MDL No. MFCD00092428
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅HCl₄N
  • Molecular Weight 216.88
  • Synonym(s) 2,3,5,6-tetrachlopyridine; 2,3,5,6-Tetrachloropyridine
  • SMILES ClC1=C(Cl)C=C(Cl)C(Cl)=N1

Description

2,3,5,6-Tetrachloropyridine is a highly chlorinated pyridine derivative featuring four chlorine atoms at the 2-, 3-, 5-, and 6-positions of the aromatic ring. This electron-deficient heterocycle serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and functionalized materials. Its stability under standard conditions enables reliable use in cross-coupling and nucleophilic substitution reactions.

Application

2,3,5,6-Tetrachloropyridine serves as a versatile electrophilic building block in heterocyclic synthesis, enabling selective functionalization at nitrogen and ortho positions. Its high reactivity facilitates nucleophilic substitution under mild conditions, making it valuable for constructing complex pyridine-based scaffolds. The molecule exhibits good bench stability and is compatible with standard purification techniques, supporting its use in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Journal of Heterocyclic Chemistry, , vol. 17, p. 493 - 496
  • Route2
    • null|null
      41797-97-1
    • ~79%
    • In-stock
      2,3,5,6-Tetrachloropyridine|CS-0128415
      2402-79-1

    References

    • Luxembourg Industries (Pamol) Ltd. Patent: US5618942 A1, 1997 ;
  • Route3
    • null|null
      74555-97-8
    • In-stock
      Perchloropyridine|CS-W010210
      2176-62-7
    • ~%
    • In-stock
      2,3,5,6-Tetrachloropyridine|CS-0128415
      2402-79-1

    References

    • US4259495 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.6952
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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