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CS-W001157 4
Total: USD 88.00

(2-Chlorothiazol-5-yl)boronic acid

  • CAS No. 2377607-88-8

  • Cat. No. CS-0162495
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2-Chlorothiazol-5-yl)boronic acid|CS-0162495

Structure of 2377607-88-8

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Description

This boronate moiety features a chlorinated thiazole ring, enhancing electronic modulation and stability. It integrates efficiently into Suzuki-Miyaura coupling reactions under standard conditions, delivering robust yields with minimal protodeboronation. The electron-deficient heterocycle enables selective functionalization in complex synthesis workflows.

Application

(2-Chlorothiazol-5-yl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to functionalized thiazole scaffolds. Its boronic acid group facilitates Suzuki-Miyaura coupling under mild conditions, while the 2-chloro substituent offers orthogonal reactivity for further derivatization. The compound exhibits good bench stability and is compatible with diverse functional groups, making it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 2377607-88-8
  • Cat. No. CS-0162495
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₃BClNO₂S
  • Molecular Weight 163.39
  • Synonym(s) (2-Chloro-1,3-thiazol-5-yl)boronic acid
  • SMILES ClC1=NC=C(B(O)O)S1

Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.5237
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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