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tert-Butyl (2S,5S)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate

  • CAS No. 2375424-00-1

  • Cat. No. CS-0146581
  • Molecule weight230.30
  • Purity≥96%
  • MDL No.MFCD32659917

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2S,5S)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate|CS-0146581

Structure of 2375424-00-1

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General Information

  • CAS No. 2375424-00-1
  • Cat. No. CS-0146581
  • Purity ≥96%
  • MDL No. MFCD32659917
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight 230.30
  • Synonym(s) 2-Methyl-2-propanyl (2S,5S)-5-(hydroxymethyl)-2-methyl-1-piperazinecarboxylate
  • SMILES O=C(N1[C@@H](C)CN[C@H](CO)C1)OC(C)(C)C

Description

This tert-butyl ester features a chiral piperazine core with a hydroxymethyl side chain, enabling direct incorporation into bioactive molecule synthesis. The protected amine and pendant alcohol facilitate selective derivatization under mild conditions, while the tert-butyl group ensures stability during purification and storage.

Application

tert-Butyl (2S,5S)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate serves as a versatile chiral building block for medicinal chemistry and peptide conjugation. The pendant hydroxymethyl group enables selective functionalization via oxidation, protection, or coupling reactions, while the piperazine core provides structural diversity and hydrogen-bonding capacity. Bench-stable and readily purified by chromatography, it facilitates efficient access to complex heterocyclic scaffolds relevant to drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   0.5761
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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