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tert-Butyl (2R)-2-(methoxymethyl)piperazine-1-carboxylate

  • CAS No. 1023301-73-6

  • Cat. No. CS-0030215
  • Purity≥97%
  • MDL No.MFCD11112288

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2R)-2-(methoxymethyl)piperazine-1-carboxylate|CS-0030215

Structure of 1023301-73-6

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General Information

  • CAS No. 1023301-73-6
  • Cat. No. CS-0030215
  • Purity ≥97%
  • MDL No. MFCD11112288
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight 230.30
  • Synonym(s) (R)-1-N-Boc-2-methoxymethylpiperazine
  • SMILES O=C(N1[C@@H](COC)CNCC1)OC(C)(C)C

Description

tert-Butyl (2R)-2-(methoxymethyl)piperazine-1-carboxylate is a chiral piperazine derivative featuring a methoxymethyl group at the 2-position and a tert-butyloxycarbonyl protecting group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds where stereochemistry influences target engagement. The compound exhibits excellent stability under standard bench conditions and facilitates efficient downstream deprotection.

Application

tert-Butyl (2R)-2-(methoxymethyl)piperazine-1-carboxylate serves as a chiral piperazine building block enabling efficient access to bioactive scaffolds. The tert-butoxycarbonyl (Boc) group provides excellent stability and orthogonal deprotection, while the methoxymethyl substituent offers a handle for further functionalization. This compound exhibits high bench stability, ease of purification, and compatibility with standard coupling reactions, facilitating its use in medicinal chemistry campaigns involving piperazine-based drug candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.8
  • LogP   0.8417
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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