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CS-W001157 4
Total: USD 88.00

Isoquinolin-7-amine

  • CAS No. 23707-37-1

  • Cat. No. CS-W018610
  • Purity≥98%
  • MDL No.MFCD08669932

*For research and further manufacturing use only, not for direct human use.

Isoquinolin-7-amine|CS-W018610

Structure of 23707-37-1

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General Information

  • CAS No. 23707-37-1
  • Cat. No. CS-W018610
  • Purity ≥98%
  • MDL No. MFCD08669932
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂
  • Molecular Weight 144.17
  • Synonym(s) Isoquinolin-7-ylamine
  • SMILES C1=NC=CC2=CC=C(C=C12)N

Description

Isoquinolin-7-amine delivers a potent nitrogen-rich heterocyclic scaffold ideal for constructing bioactive molecules. This bench-stable amine features a strategically positioned amino group at the 7-position, enabling efficient coupling reactions and facilitating integration into pharmaceutical intermediates, agrochemicals, and functional materials through straightforward derivatization pathways.

Application

Isoquinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed coupling reactions. Its nitrogen-rich scaffold exhibits strong electron-donating character, facilitating functionalization at the 7-position and enhancing solubility in polar solvents. Bench-stable and readily purified by recrystallization, it functions effectively in SNAr processes and as a ligand precursor in transition metal catalysis.

Synthesis

  • Route1

    References

    • WO2006/12374 A1, ; Page/Page column 227 ; WO 2006/012374 A1
  • Route2

    References

    • Journal of the Chemical Society, , p. 2851
  • Route3

    References

    • Journal of the Chemical Society, , p. 4191,4205 Journal of the American Chemical Society, , vol. 69, p. 1939,1941

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.817
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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