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CS-W001157 4
Total: USD 88.00

1,3,5-Tribromo-2,4,6-trifluorobenzene

  • CAS No. 2368-49-2

  • Cat. No. CS-0197066
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3,5-Tribromo-2,4,6-trifluorobenzene|CS-0197066

Structure of 2368-49-2

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General Information

  • CAS No. 2368-49-2
  • Cat. No. CS-0197066
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆Br₃F₃
  • Molecular Weight 368.77
  • Synonym(s) Benzene, 1,3,5-tribromo-2,4,6-trifluoro-
  • SMILES FC1=C(Br)C(F)=C(Br)C(F)=C1Br

Description

1,3,5-Tribromo-2,4,6-trifluorobenzene is a highly fluorinated, electron-deficient aromatic scaffold featuring three bromine substituents at the 1,3,5-positions and three fluorine atoms at the 2,4,6-positions. This symmetric arrangement imparts exceptional stability and enhances reactivity in palladium-catalyzed cross-coupling processes. The molecule’s steric and electronic profile enables efficient integration into complex molecular architectures under standard conditions.

Application

1,3,5-Tribromo-2,4,6-trifluorobenzene serves as a versatile building block in fluorinated aromatic synthesis, enabling efficient construction of complex heterocycles and functionalized scaffolds. Its high reactivity in palladium-catalyzed cross-coupling reactions stems from the synergistic electronic effects of bromine and fluorine substituents. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it ideal for iterative synthetic sequences in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.3914
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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