Lot numbers can be found on the outside label of a product:
N-Methyl-2-nitrobenzenesulfonamide
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CAS No. 23530-40-7
- Cat. No. CS-M2486
- Purity≥98%
- MDL No.MFCD01115621
*For research and further manufacturing use only, not for direct human use.
Structure of 23530-40-7
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General Information
- CAS No. 23530-40-7
- Cat. No. CS-M2486
- Purity ≥98%
- MDL No. MFCD01115621
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₈N₂O₄S
- Molecular Weight 216.21
- Synonym(s) N-Methyl-2-nitrobenzenesulphonamide
- SMILES O=S(C1=C([N+]([O-])=O)C=CC=C1)(NC)=O
Description
N-Methyl-2-nitrobenzenesulfonamide features a sulfonamide group flanked by an electron-deficient aromatic ring and a methyl substituent, enhancing stability and solubility in organic media. This configuration supports its role as a key intermediate in the synthesis of bioactive sulfonamide derivatives, particularly in medicinal chemistry applications requiring robust functional group tolerance under standard conditions.
Application
N-Methyl-2-nitrobenzenesulfonamide serves as a stable, bench-ready sulfonamide building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-nitro group enables directed metalation and subsequent functionalization, while the N-methyl sulfonamide moiety offers enhanced solubility and metabolic stability. The compound facilitates efficient coupling reactions and acts as a versatile scaffold in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.
Synthesis
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Route1
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1694-92-4 -
74-89-5
- ~91%
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In-stock
23530-40-7
References
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Vogensen, Stine B.; Jorgensen, Lars; Madsen, Karsten K.; Borkar, Nrupa; Wellendorph, Petrine; Skovgaard-Petersen, Jonas; Schousboe, Arne; White, H. Steve; Krogsgaard-Larsen, Povl; Clausen, Rasmus P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 2160 - 2164
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Route2
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593-51-1
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1694-92-4
- ~63%
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In-stock
23530-40-7
References
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BIOLIPOX AB Patent: WO2007/45868 A1, 2007 ; Location in patent: Page/Page column 47 ;
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Route3
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1026978-85-7
- ~%
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In-stock
23530-40-7
References
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Journal of Organic Chemistry, , vol. 62, # 6 p. 1580 - 1581
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 89.31
- LogP 0.5029
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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