Lot numbers can be found on the outside label of a product:
2-Amino-N-methylbenzenesulfonamide
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CAS No. 16288-77-0
- Cat. No. CS-M2487
- Purity≥95%
- MDL No.MFCD04035388
*For research and further manufacturing use only, not for direct human use.
Structure of 16288-77-0
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General Information
- CAS No. 16288-77-0
- Cat. No. CS-M2487
- Purity ≥95%
- MDL No. MFCD04035388
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₀N₂O₂S
- Molecular Weight 186.23
- Synonym(s) N-Methyl-2-aminobenzenesulfonamide
- SMILES O=S(C(C=CC=C1)=C1N)(NC)=O
Description
2-Amino-N-methylbenzenesulfonamide features a sulfonamide group conjugated to an aromatic ring bearing a methylated amine substituent. This combination imparts enhanced solubility and metabolic stability, making it suitable for medicinal chemistry applications involving targeted kinase inhibition and scaffold diversification in drug discovery programs.
Application
2-Amino-N-methylbenzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing scaffolds through standard coupling and derivatization reactions. Its amine and sulfonamide functionalities offer orthogonal reactivity for modular synthesis, while the N-methyl group enhances metabolic stability and membrane permeability. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative library synthesis and lead optimization campaigns.
Synthesis
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Route1
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In-stock
23530-40-7 - ~95%
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In-stock
16288-77-0
References
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CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; CHENG, Liang; LIU, Xijie; HU, Yuandong; XU, Xinhe; LIU, Zhihua; ZHANG, Lipeng; WU, Wei; WANG, Shulong; SHEN, Yu; LI, Gen; WANG, Yin; ZHAO, Sheng; LI, Chonglong; TANG, Jia; YU, Honghao Patent: WO2012/92880 A1, 2012 ; Location in patent: Page/Page column 64 ; WO 2012/092880 A1
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Route2
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1694-92-4 - ~%
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In-stock
16288-77-0
References
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WO2011/140338 A1, ;
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Route3
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7781-47-7
- ~%
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In-stock
16288-77-0
References
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Farmaco, Edizione Scientifica, , vol. 12, p. 483,491
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 72.19
- LogP 0.1769
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 2
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Key Words
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