(3R,6R)-1-tert-Butyl 3-methyl 6-methylpiperazine-1,3-dicarboxylate

Name: (3R,6R)-1-tert-Butyl 3-methyl 6-methylpiperazine-1,3-dicarboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 2349395-78-2
Cat. No. CS-0099059
Purity≥97%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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(3R,6R)-1-tert-Butyl 3-methyl 6-methylpiperazine-1,3-dicarboxylate|CS-0099059

Structure of 2349395-78-2

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Description

This chiral piperazine derivative features a rigid, sterically defined scaffold with two methylated ring positions and a tert-butyl ester group. The (3R,6R) stereochemistry ensures high diastereoselectivity in downstream transformations. The molecule integrates readily into complex heterocyclic architectures, offering enhanced solubility and stability under standard bench conditions.

Application

(3R,6R)-1-tert-Butyl 3-methyl 6-methylpiperazine-1,3-dicarboxylate serves as a stereochemically defined piperazine building block for medicinal chemistry and asymmetric synthesis. Its rigid, enantiopure framework facilitates controlled functionalization at both nitrogen centers, enabling access to complex heterocyclic scaffolds. The tert-butyl and methyl substituents provide steric protection and enhanced bench stability, while the dicarboxylate groups offer orthogonal handles for selective deprotection and conjugation in multi-step syntheses.

General Information

CAS No. 2349395-78-2
Cat. No. CS-0099059
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₄
Molecular Weight 258.31
Synonym(s) Methyl (2R,5R)-4-Boc-5-methylpiperazine-2-carboxylate
SMILES O=C(N1C[C@H](C(OC)=O)NC[C@H]1C)OC(C)(C)C

Computational Chemistry Data

TPSA 67.87
LogP 0.7568
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(3R,6R)-1-tert-Butyl 3-methyl 6-methylpiperazine-1,3-dicarboxylate

CAS No. 2349395-78-2

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