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CS-W001157 4
Total: USD 88.00

2-Ethylbenzene-1,4-diol

  • CAS No. 2349-70-4

  • Cat. No. CS-0152526
  • Purity≥95%
  • MDL No.MFCD00017398

*For research and further manufacturing use only, not for direct human use.

2-Ethylbenzene-1,4-diol|CS-0152526

Structure of 2349-70-4

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General Information

  • CAS No. 2349-70-4
  • Cat. No. CS-0152526
  • Purity ≥95%
  • MDL No. MFCD00017398
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂
  • Molecular Weight 138.16
  • Synonym(s) 1,4-DIHYDROXY-2-ETHYLBENZENE
  • SMILES CCC1=CC(=CC=C1O)O

Description

2-Ethylbenzene-1,4-diol features a para-substituted aromatic core with two hydroxyl groups and a C2 alkyl side chain, offering enhanced solubility and stability in organic synthesis. This electron-rich scaffold serves as a key building block for functionalized phenolic compounds used in pharmaceutical intermediates and advanced materials.

Application

2-Ethylbenzene-1,4-diol serves as a versatile dihydroxy aromatic building block for the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-diol functionality enables selective protection, oxidation to quinones, or coordination in transition metal-catalyzed coupling reactions. The ethyl substituent provides steric and electronic modulation while maintaining bench stability and compatibility with standard purification protocols.

Synthesis

  • Route1
    • null|null
      31490-53-6
    • ~90%
    • In-stock
      2-Ethylbenzene-1,4-diol|CS-0152526
      2349-70-4

    References

    • JUBILANT BIOSYS LTD.; SARMA, Pakala Kumara Savithru; ACHARYA, Vinod Parameshwaran; KASIBHATLA, Srinivas Rao; VISWANADHAN, Vellarkad Narayana; TIWARI, Atul; SINGHA, Rakesh Kumar; BISCHOFF, Alexander Patent: WO2012/90219 A2, 2012 ; Location in patent: Page/Page column 83 ;
  • Route2

    References

    • Bulletin des Societes Chimiques Belges, , vol. 74, p. 397 - 406
  • Route3
    • null|null
      1187824-35-6
    • ~%
    • In-stock
      2-Ethylbenzene-1,4-diol|CS-0152526
      2349-70-4

    References

    • Organic Letters, , vol. 11, # 19 p. 4322 - 4325

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.6602
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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