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CS-W001157 4
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5-Ethynyl-1H-pyrazole

  • CAS No. 23486-70-6

  • Cat. No. CS-0309386
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Ethynyl-1H-pyrazole|CS-0309386

Structure of 23486-70-6

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General Information

  • CAS No. 23486-70-6
  • Cat. No. CS-0309386
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂
  • Molecular Weight 92.10
  • Synonym(s) 3-Ethynyl-1H-pyrazole
  • SMILES C#CC1=CC=NN1

Description

5-Ethynyl-1H-pyrazole features a terminal alkyne group appended to the pyrazole ring, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and molecular scaffolding. The electron-deficient heterocycle enhances reactivity in click chemistry applications, while the bench-stable alkyne tolerates standard handling conditions. This compound integrates readily into complex architectures via modular coupling strategies.

Application

5-Ethynyl-1H-pyrazole serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne moiety facilitates reliable conjugation reactions, while the pyrazole core provides robust stability and compatibility with diverse reaction conditions. This compound is particularly valuable for constructing triazole-linked scaffolds in medicinal chemistry and materials science applications, offering high yield and ease of purification in standard bench-scale syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   0.391
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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