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Structure of 23443-05-2
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5-Chloroquinolin-4-ol delivers a rigid, electron-deficient quinoline scaffold bearing a strategically positioned hydroxyl group. This combination enables direct functionalization at the 4-position and enhances solubility in polar solvents. The chloro substituent at the 5-position supports further derivatization via cross-coupling reactions. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and antimalarial agents.
5-Chloroquinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or transition-metal-catalyzed coupling. The chloro group exhibits high reactivity under palladium-catalyzed conditions, while the phenolic hydroxyl offers orthogonal handling for derivatization. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of quinoline-based pharmaceutical scaffolds and agrochemical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: