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CS-W001157 4
Total: USD 88.00

4-Chloroquinolin-7-ol

  • CAS No. 181950-57-2

  • Cat. No. CS-W019012
  • Purity≥98%
  • MDL No.MFCD09261120

*For research and further manufacturing use only, not for direct human use.

4-Chloroquinolin-7-ol|CS-W019012

Structure of 181950-57-2

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General Information

  • CAS No. 181950-57-2
  • Cat. No. CS-W019012
  • Purity ≥98%
  • MDL No. MFCD09261120
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆ClNO
  • Molecular Weight 179.60
  • Synonym(s) 4-Chloro-7-hydroxyquinoline
  • SMILES OC1=CC=C2C(Cl)=CC=NC2=C1

Description

4-Chloroquinolin-7-ol features a quinoline core with strategic substitution at the 4-chloro and 7-hydroxyl positions, enabling its use in medicinal chemistry scaffolds. The electron-deficient aromatic system pairs with a phenolic hydroxyl group, facilitating hydrogen bonding and serving as a handle for derivatization. This compound demonstrates stability under standard bench conditions and is compatible with common synthetic transformations.

Application

4-Chloroquinolin-7-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution and transition metal-mediated transformations, while the phenolic hydroxyl group offers orthogonal reactivity for derivatization. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of quinoline-based scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.5938
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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