Lot numbers can be found on the outside label of a product:
1-(2-Amino-5-fluorophenyl)ethanone
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CAS No. 2343-25-1
- Cat. No. CS-W005413
- Purity≥97%
- MDL No.MFCD09835333
*For research and further manufacturing use only, not for direct human use.
Structure of 2343-25-1
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General Information
- CAS No. 2343-25-1
- Cat. No. CS-W005413
- Purity ≥97%
- MDL No. MFCD09835333
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈FNO
- Molecular Weight 153.15
- Synonym(s) Ethanone, 1-(2-amino-5-fluorophenyl)-
- SMILES CC(=O)C1=C(N)C=CC(F)=C1
Description
1-(2-Amino-5-fluorophenyl)ethanone features a fluorinated aromatic ring paired with a reactive acetamido group, enabling direct integration into pharmaceutical scaffolds. The para-fluoro substitution enhances metabolic stability, while the amino functionality supports facile derivatization under standard conditions. This compound serves as a key intermediate in the synthesis of bioactive molecules targeting neurological and oncological pathways.
Application
1-(2-Amino-5-fluorophenyl)ethanone serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds. Its ortho-amino and fluoro substituents enable directed metalation and facilitate transition-metal-catalyzed coupling reactions. The ketone functionality supports nucleophilic additions and reductive transformations, offering reliable access to substituted anilines and heterocyclic intermediates in medicinal chemistry workflows. Bench-stable and amenable to standard purification methods, it functions effectively in multi-step syntheses requiring functional group compatibility.
Synthesis
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Route1
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In-stock
61272-77-3 -
75-16-1 - ~51%
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In-stock
2343-25-1
References
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H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro Patent: WO2013/50527 A1, 2013 ; Location in patent: Page/Page column 45; 46 ;
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Route2
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75-05-8
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371-40-4
- ~%
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In-stock
2343-25-1
References
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Liu, Yong; Chen, Hui; Hu, Xiong; Zhou, Wang; Deng, Guo-Jun European Journal of Organic Chemistry, 2013 , # 20 p. 4229 - 4232
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Route3
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In-stock
351-83-7 - ~%
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In-stock
2343-25-1
References
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Guerrini, Giacomo; Taddei, Maurizio; Ponticelli, Fabio Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7597 - 7601
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.09
- LogP 1.6105
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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