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CS-W001157 4
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3-Hydroxy-1,8-naphthalic anhydride

  • CAS No. 23204-36-6

  • Cat. No. CS-0210252
  • Purity≥98%
  • MDL No.MFCD00059759

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-1,8-naphthalic anhydride|CS-0210252

Structure of 23204-36-6

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General Information

  • CAS No. 23204-36-6
  • Cat. No. CS-0210252
  • Purity ≥98%
  • MDL No. MFCD00059759
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₆O₄
  • Molecular Weight 214.17
  • Synonym(s) hydroxynaphthalicanhydride
  • SMILES C1=CC2=CC(=CC3=C2C(=C1)C(=O)OC3=O)O

Description

3-Hydroxy-1,8-naphthalic anhydride features a reactive anhydride moiety flanked by a phenolic hydroxyl group, enabling direct coupling in synthesis. This bifunctional scaffold integrates readily into complex molecular architectures under mild conditions, offering high stability and predictable reactivity for applications in organic synthesis and materials science.

Application

3-Hydroxy-1,8-naphthalic anhydride serves as a versatile building block in synthetic organic chemistry, enabling the construction of substituted naphthalene scaffolds through facile functional group transformations. Its dual functionality—carboxylic anhydride and phenolic hydroxyl—supports orthogonally controlled derivatization, including amidation, esterification, and ether formation. The compound exhibits good bench stability and facilitates efficient purification via recrystallization, making it well-suited for use in medicinal chemistry campaigns and materials synthesis.

Synthesis

  • Route1
    • 1,3-Dioxo-1H,3H-benzo[de]isochromene-5-sulfonic acid|CS-1157295
      69409-07-0
    • ~78%
    • In-stock
      3-Hydroxy-1,8-naphthalic anhydride|CS-0210252
      23204-36-6

    References

    • Brown, Roger F. C.; Coulston, Karen J.; Eastwood, Frank W.; Saminathan, Sugirtham Australian Journal of Chemistry, 1987 , vol. 40, # 1 p. 107 - 120
  • Route2

    References

    • Chem. News J. Ind. Sci., , vol. 98, p. 279 Chem. Zentralbl., , vol. 80, # I p. 1876
  • Route3
    • null|null
      174530-06-4
    • ~%
    • In-stock
      3-Hydroxy-1,8-naphthalic anhydride|CS-0210252
      23204-36-6

    References

    • Chemische Berichte, , vol. 32, p. 3290 Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5>14 II, p. 689 Gazzetta Chimica Italiana, , vol. 36, p. II,107

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   1.856
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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