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CS-W001157 4
Total: USD 88.00

(3-Chlorophenyl)hydrazine hydrochloride

  • CAS No. 2312-23-4

  • Cat. No. CS-W017297
  • Purity≥97%
  • MDL No.MFCD00012935

*For research and further manufacturing use only, not for direct human use.

(3-Chlorophenyl)hydrazine hydrochloride|CS-W017297

Structure of 2312-23-4

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General Information

  • CAS No. 2312-23-4
  • Cat. No. CS-W017297
  • Purity ≥97%
  • MDL No. MFCD00012935
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈Cl₂N₂
  • Molecular Weight 179.05
  • Synonym(s) m-Chlorophenylhydrazine hydrochloride
  • SMILES ClC1=CC(NN)=CC=C1.Cl

Description

(3-Chlorophenyl)hydrazine hydrochloride is a bench-stable hydrazine derivative featuring a chlorinated aromatic ring, enabling direct incorporation into heterocyclic syntheses. This reagent facilitates efficient access to triazoles and other nitrogen-rich scaffolds under mild conditions, offering reliable coupling performance in medicinal chemistry applications.

Application

(3-Chlorophenyl)hydrazine hydrochloride serves as a reliable building block for the synthesis of heterocyclic compounds, particularly in the construction of pyrazoles and triazoles via cyclocondensation reactions. Its well-documented reactivity enables efficient coupling with carbonyl-containing substrates under mild conditions, offering high functional group tolerance and ease of purification. The compound exhibits good bench stability and is readily handled in standard laboratory workflows, making it a practical choice for medicinal chemistry and process development applications.

Synthesis

  • Route1
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      108-42-9
    • ~%
    • (3-Chlorophenyl)hydrazine hydrochloride|CS-W017297
      2312-23-4

    References

    • Archiv der Pharmazie (Weinheim, Germany), , vol. 327, # 2 p. 99 - 104
  • Route2
    • null|null
      121-73-3
    • ~%
    • (3-Chlorophenyl)hydrazine hydrochloride|CS-W017297
      2312-23-4

    References

    • Journal of Medicinal Chemistry, , vol. 47, # 26 p. 6603 - 6608

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1(b)
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.0474
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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