(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride

Name: (3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 2306246-40-0
Cat. No. CS-0527834
Purity≥96%
MDL No.MFCD31743843

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride|CS-0527834

Structure of 2306246-40-0

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Description

This dihydrochloride salt features a chiral piperidine core with fluorine at the 3-position and a methyl group at nitrogen, delivering enhanced metabolic stability and improved membrane permeability. The protonated amine centers ensure high solubility in aqueous media, facilitating use in medicinal chemistry workflows. Designed for efficient incorporation into bioactive molecules, this scaffold supports rapid structure-activity optimization in CNS-targeted drug discovery.

Application

(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride serves as a key chiral building block in medicinal chemistry, enabling the construction of fluorinated piperidine scaffolds prevalent in bioactive molecules. Its defined stereochemistry and protonatable nitrogen atoms facilitate efficient incorporation into drug candidates via standard amine coupling and reductive amination protocols. The dihydrochloride salt enhances solubility and stability for handling and purification, supporting robust performance in multi-step syntheses and scale-up processes.

General Information

CAS No. 2306246-40-0
Cat. No. CS-0527834
Purity ≥96%
MDL No. MFCD31743843
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₅Cl₂FN₂
Molecular Weight 205.10
Synonym(s) None
SMILES F[C@@H]1[C@@H](CCN(C1)C)N.Cl.Cl

Computational Chemistry Data

TPSA 29.26
LogP 0.8309
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Drug Discovery Cancer P53

Key Words

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(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride

CAS No. 2306246-40-0

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