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CS-W001157 4
Total: USD 88.00

4-Chloro-2-methyl-3-nitropyridine

  • CAS No. 23056-35-1

  • Cat. No. CS-0147960
  • Purity≥95%
  • MDL No.MFCD11215572
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-methyl-3-nitropyridine|CS-0147960

Structure of 23056-35-1

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Description

4-Chloro-2-methyl-3-nitropyridine is a bench-stable heterocyclic building block featuring a nitro group at the 3-position and a chloro substituent at the 4-position, enabling diverse coupling reactions. The methyl group enhances regioselectivity in electrophilic substitutions, while the electron-deficient pyridine ring supports nucleophilic aromatic substitution under mild conditions. This compound integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds.

Application

4-Chloro-2-methyl-3-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The chloro group exhibits high reactivity under standard conditions, while the nitro and methyl functionalities provide orthogonal handles for sequential functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 23056-35-1
  • Cat. No. CS-0147960
  • Purity ≥95%
  • MDL No. MFCD11215572
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₂
  • Molecular Weight 172.57
  • Synonym(s) 4-CHLORO-2-METHYL-3-NITRO-PYRIDINE
  • SMILES O=[N+](C1=C(Cl)C=CN=C1C)[O-]

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.95162
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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