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CS-W001157 4
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Quinoline-5-carbaldehyde

  • CAS No. 22934-41-4

  • Cat. No. CS-0187625
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Quinoline-5-carbaldehyde|CS-0187625

Structure of 22934-41-4

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General Information

  • CAS No. 22934-41-4
  • Cat. No. CS-0187625
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO
  • Molecular Weight 157.17
  • Synonym(s) Quinoline-5-carboxaldehyde
  • SMILES C1=CC(=C2C=CC=NC2=C1)C=O

Description

Quinoline-5-carbaldehyde delivers a rigid, electron-deficient heteroaromatic scaffold ideal for transition metal-catalyzed coupling reactions. The aldehyde functionality enables direct integration into complex molecular architectures, while the quinoline core provides enhanced solubility and stability under standard conditions.

Application

Quinoline-5-carbaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds through standard carbonyl transformations. Its aldehyde functionality exhibits reliable reactivity in nucleophilic additions, condensations, and coupling reactions, with high bench stability and straightforward purification. The quinoline core provides excellent planarity and π-conjugation, enhancing its utility in developing bioactive compounds and functional materials.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1803 - 1810
  • Route2
    • ethyl quinoline-5-carboxylate|CS-0038733
      98421-25-1
    • ~%
    • In-stock
      Quinoline-5-carbaldehyde|CS-0187625
      22934-41-4

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1803 - 1810
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1803 - 1810

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.0473
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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