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CS-W001157 4
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(4-(Pyrrolidin-1-yl)phenyl)boronic acid

  • CAS No. 229009-41-0

  • Cat. No. CS-0044978
  • Molecule weight191.03
  • Purity≥98%
  • MDL No.MFCD03095137

*For research and further manufacturing use only, not for direct human use.

(4-(Pyrrolidin-1-yl)phenyl)boronic acid|CS-0044978

Structure of 229009-41-0

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General Information

  • CAS No. 229009-41-0
  • Cat. No. CS-0044978
  • Purity ≥98%
  • MDL No. MFCD03095137
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄BNO₂
  • Molecular Weight 191.03
  • Synonym(s) 4-(Pyrrolidino-N-yl)phenylboronic acid
  • SMILES OB(C1=CC=C(N2CCCC2)C=C1)O

Description

This boronic acid features a pyrrolidinyl-modified aryl group, enhancing solubility and stability in polar solvents. The pendant amine moiety enables facile derivatization and coordination in catalytic systems. Designed for efficient cross-coupling reactions under mild conditions, it integrates readily into complex molecular architectures with improved handling characteristics compared to standard phenylboronic acids.

Application

(4-(Pyrrolidin-1-yl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures under mild conditions. The pyrrolidinyl group enhances solubility and modulates electronic properties, while the boronic acid functionality offers excellent stability and compatibility with diverse functional groups. Its bench-stable nature and straightforward purification make it ideal for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.7
  • LogP   -0.0334
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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