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Structure of 22821-76-7
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4-(Methylsulfonyl)benzonitrile features a para-substituted aromatic core bearing both a nitrile and a methylsulfonyl group, enabling its use in constructing electron-deficient heterocycles. The sulfonyl moiety enhances solubility and metabolic stability, while the nitrile serves as a key handle for nucleophilic transformations. This compound is bench-stable and compatible with standard coupling protocols.
4-(Methylsulfonyl)benzonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and functionalized aryl scaffolds. Its dual functionality—electron-withdrawing nitrile and sulfone groups—facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse reaction conditions, making it ideal for iterative synthesis and library generation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P501
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Lot numbers can be found on the outside label of a product: