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Structure of 227609-88-3
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4-Fluoro-3-iodobenzaldehyde features a fluorinated aromatic ring bearing strategically positioned iodide and aldehyde functionalities. This combination enables direct incorporation into cross-coupling reactions, particularly Suzuki-Miyaura and Negishi transformations, where the iodide acts as a high-reactivity handle. The electron-withdrawing fluorine substituent modulates reactivity and enhances metabolic stability in bioactive molecule synthesis.
4-Fluoro-3-iodobenzaldehyde serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryl scaffolds. The ortho-iodo and para-fluoro groups offer orthogonal reactivity for sequential functionalization, while the aldehyde functionality permits facile derivatization via condensation or reduction. Bench-stable and compatible with standard reaction conditions, it facilitates streamlined synthesis of complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: