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2-Fluoro-3-iodobenzaldehyde

  • CAS No. 146137-83-9

  • Cat. No. CS-0109989
  • Purity≥97%
  • MDL No.MFCD15528731

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-iodobenzaldehyde|CS-0109989

Structure of 146137-83-9

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General Information

  • CAS No. 146137-83-9
  • Cat. No. CS-0109989
  • Purity ≥97%
  • MDL No. MFCD15528731
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FIO
  • Molecular Weight 250.01
  • Synonym(s) 2-Fluoro-3-iodo-benzaldehyde
  • SMILES O=CC1=CC=CC(I)=C1F

Description

2-Fluoro-3-iodobenzaldehyde features a fluorinated aromatic ring paired with iodine and aldehyde functionalities, enabling direct coupling in cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity, while the iodide serves as a high-efficiency handle for palladium-catalyzed transformations. This compound offers excellent stability under standard conditions and integrates readily into complex molecular architectures.

Application

2-Fluoro-3-iodobenzaldehyde serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryls and heterocycles. Its ortho-fluoro and iodo substituents provide orthogonal reactivity for sequential functionalization, while the aldehyde group offers direct handle for further transformations. The compound exhibits good bench stability and is compatible with standard synthetic workflows, facilitating rapid diversification in medicinal chemistry and materials synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2428
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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