Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Name: Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
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CAS No. 2264011-98-3
Cat. No. CS-0159204
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH|CS-0159204

Structure of 2264011-98-3

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General Information

CAS No. 2264011-98-3
Cat. No. CS-0159204
Purity ≥95%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₃H₃₅N₅O₉
Molecular Weight 645.66
Synonym(s) None
SMILES OC(COCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O)=O)=O

Description

Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a peptide derivative featuring a C-terminal ester-linked carboxylic acid, enabling efficient conjugation in bioconjugation workflows. The Fmoc group ensures orthogonal protection during solid-phase synthesis, while the glycine-rich sequence provides flexibility and solubility. This structure facilitates site-specific labeling and incorporation into larger biomolecular constructs under standard conditions.

Application

Fmoc-Gly-Gly-Phe-Gly-NH-CH₂-O-CH₂COOH serves as a well-defined peptide-based building block for the synthesis of cyclic or constrained peptide scaffolds. The Fmoc group enables efficient solid-phase peptide synthesis, while the C-terminal hydroxymethyl ester facilitates conjugation and derivatization. Its sequence incorporates orthogonal protection and stable linkages, offering reliable handling and purification in multi-step synthetic workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 201.26
LogP 0.6599
H_Acceptors 8
H_Donors 6
Rotatable_Bonds 16

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

CAS No. 2264011-98-3

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