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2-Bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

  • CAS No. 226386-47-6

  • Cat. No. CS-0060818
  • Purity≥97%
  • MDL No.MFCD11042754

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine|CS-0060818

Structure of 226386-47-6

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General Information

  • CAS No. 226386-47-6
  • Cat. No. CS-0060818
  • Purity ≥97%
  • MDL No. MFCD11042754
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNS
  • Molecular Weight None
  • Synonym(s) None
  • SMILES C1CNCC2=C1SC(=C2)Br

Description

2-Bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine features a fused thienopyridine core with a bromine substituent at the 2-position, enabling direct functionalization in cross-coupling reactions. The saturated thiophene ring enhances solubility and stability under standard conditions, while the electron-deficient heterocycle facilitates transition metal-catalyzed transformations. This scaffold serves as a key building block for bioactive molecules and advanced materials.

Application

2-Bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine serves as a versatile scaffold for constructing biologically relevant heterocycles, enabling efficient Pd-catalyzed cross-coupling reactions. The bromine substituent provides high reactivity in standard Suzuki, Stille, and Negishi couplings, while the saturated thienopyridine core offers enhanced stability and solubility. Its functional group tolerance facilitates downstream derivatization in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.1563
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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