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Structure of 22515-18-0
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4,4-Difluorocyclohexanone features a strained cyclohexanone core bearing two fluorine atoms at the C4 position, enhancing electrophilicity and directing regioselective functionalization. This bench-stable ketone integrates readily into synthetic sequences requiring polarized carbonyl reactivity with improved metabolic stability in bioactive molecule design.
4,4-Difluorocyclohexanone serves as a valuable building block in medicinal chemistry and synthetic organic chemistry, offering enhanced metabolic stability and altered electronic properties due to the geminal difluoro substitution. Its carbonyl group enables reliable enolization, nucleophilic addition, and conjugate addition reactions, while the fluorine atoms provide favorable lipophilicity and steric profile. The compound exhibits good bench stability and is compatible with standard functional group manipulations, facilitating its use in constructing fluorinated heterocycles and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: