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Structure of 22419-35-8
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4,4-Difluorocyclohexanol features a rigid cyclohexane core bearing two fluorine atoms at the 4-position and a hydroxyl group at the same carbon. This configuration imparts enhanced stability and polarity, enabling its use in building complex fluorinated scaffolds for medicinal chemistry and materials science applications.
4,4-Difluorocyclohexanol serves as a valuable fluorinated building block in medicinal chemistry, offering enhanced metabolic stability and modulated lipophilicity. Its equatorial hydroxyl group enables predictable stereochemistry in downstream transformations, while the geminal difluoro substitution imparts resistance to oxidative degradation. The compound exhibits good bench stability and facilitates efficient functionalization via nucleophilic substitution or elimination reactions, making it suitable for constructing complex fluorinated scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: