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CS-W001157 4
Total: USD 88.00

Thalidomide-O-amido-C4-NH2 (hydrochloride)

  • CAS No. 2245697-86-1

  • Cat. No. CS-0120127
  • Purity≥98%
  • MDL No.MFCD31630818

*For research and further manufacturing use only, not for direct human use.

Thalidomide-O-amido-C4-NH2 (hydrochloride)|CS-0120127

Structure of 2245697-86-1

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General Information

  • CAS No. 2245697-86-1
  • Cat. No. CS-0120127
  • Purity ≥98%
  • MDL No. MFCD31630818
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₃ClN₄O₆
  • Molecular Weight 438.86
  • Synonym(s) None
  • SMILES NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.Cl

Description

Thalidomide-O-amido-C4-NH2 (hydrochloride) features a C4-aminobutyl linker attached to the O-position of thalidomide, enabling conjugation in bioconjugation workflows. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating handling in synthetic and medicinal chemistry applications.

Application

Thalidomide-O-amido-C4-NH2 (hydrochloride) serves as a versatile scaffold for targeted protein degradation and medicinal chemistry studies. The C4-amine linker enables site-specific conjugation to bifunctional molecules, while the O-amido modification enhances stability and modulates solubility. This derivative maintains key pharmacophoric elements of thalidomide, facilitating exploration of cereblon E3 ligase engagement in PROTAC design. Its hydrochloride salt ensures improved handling and storage stability, supporting reliable use in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   147.9
  • LogP   -0.2565
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   8

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