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Structure of 2245697-86-1
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Thalidomide-O-amido-C4-NH2 (hydrochloride) features a C4-aminobutyl linker attached to the O-position of thalidomide, enabling conjugation in bioconjugation workflows. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating handling in synthetic and medicinal chemistry applications.
Thalidomide-O-amido-C4-NH2 (hydrochloride) serves as a versatile scaffold for targeted protein degradation and medicinal chemistry studies. The C4-amine linker enables site-specific conjugation to bifunctional molecules, while the O-amido modification enhances stability and modulates solubility. This derivative maintains key pharmacophoric elements of thalidomide, facilitating exploration of cereblon E3 ligase engagement in PROTAC design. Its hydrochloride salt ensures improved handling and storage stability, supporting reliable use in synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: