Thalidomide-1-Me,4-OH

Name: Thalidomide-1-Me,4-OH
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CAS No. 2244568-06-5
Cat. No. CS-0436791
Purity≥98%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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General Information

CAS No. 2244568-06-5
Cat. No. CS-0436791
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₂N₂O₅
Molecular Weight 288.26
Synonym(s) None
SMILES O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3O)=O

Description

Thalidomide-1-Me,4-OH features a methylated 1-position and hydroxylated 4-position, enhancing metabolic stability and modulating biological activity. This derivative retains the core phthalimide scaffold with altered electronic and steric properties, enabling selective modulation of target proteins in inflammatory and oncogenic pathways.

Application

Thalidomide-1-Me,4-OH serves as a structurally defined analog of thalidomide, featuring methyl substitution at the 1-position and hydroxyl functionality at the 4-position. This derivative maintains the core phthalimide scaffold while enhancing solubility and metabolic stability. It functions as a versatile building block in medicinal chemistry campaigns targeting immunomodulatory and antiangiogenic activity, enabling direct evaluation of substituent effects on biological potency and pharmacokinetic profiles.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 94.99
LogP 0.0166
H_Acceptors 7
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Phenol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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Thalidomide-1-Me,4-OH

CAS No. 2244568-06-5

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