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CS-W001157 4
Total: USD 88.00

N-Me-Thalidomide 4-fluoride

  • CAS No. 2244520-92-9

  • Cat. No. CS-0527789
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-Me-Thalidomide 4-fluoride|CS-0527789

Structure of 2244520-92-9

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General Information

  • CAS No. 2244520-92-9
  • Cat. No. CS-0527789
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁FN₂O₄
  • Molecular Weight 290.25
  • Synonym(s) None
  • SMILES O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(F)=CC=C2

Description

N-Me-Thalidomide 4-fluoride features a methylated amide nitrogen and a para-fluorine substituent, enhancing metabolic stability and modulating electronic properties. This derivative exhibits improved lipophilicity and bench-stability compared to parent thalidomide, facilitating direct incorporation into medicinal chemistry campaigns targeting immunomodulatory pathways.

Application

N-Me-Thalidomide 4-fluoride serves as a synthetically accessible analog for probing the structure-activity relationships of immunomodulatory imide drugs. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the N-methyl substitution improves solubility and pharmacokinetic profile. The compound functions as a versatile building block in medicinal chemistry campaigns targeting cereblon-binding scaffolds, enabling efficient synthesis of derivatives via standard coupling and functionalization protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   74.76
  • LogP   0.4631
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   1

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