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CS-W001157 4
Total: USD 88.00

4-Amino-5-methylpyrimidine

  • CAS No. 22433-68-7

  • Cat. No. CS-W019019
  • Purity≥98%
  • MDL No.MFCD09909807

*For research and further manufacturing use only, not for direct human use.

4-Amino-5-methylpyrimidine|CS-W019019

Structure of 22433-68-7

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General Information

  • CAS No. 22433-68-7
  • Cat. No. CS-W019019
  • Purity ≥98%
  • MDL No. MFCD09909807
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) 4-Pyrimidinamine, 5-methyl- (9CI)
  • SMILES NC1=NC=NC=C1C

Description

4-Amino-5-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering a polar amine group and a methyl substituent that enhance solubility and metabolic stability. This pyrimidine derivative integrates readily into kinase inhibitors and nucleoside analogs, where its electron-rich core supports hydrogen bonding and targeted receptor engagement under standard bench conditions.

Application

4-Amino-5-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. Its amino and methyl groups offer orthogonal functionalization sites, supporting diverse derivatization via coupling, alkylation, or transition-metal-catalyzed transformations. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 59, p. 526,527
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 59, p. 526,527
  • Route3
    • 2,6-Dichloro-5-methylpyrimidin-4-amine|CS-0045657
      95520-61-9
    • ~%
    • In-stock
      4-Amino-5-methylpyrimidine|CS-W019019
      22433-68-7

    References

    • Chemische Berichte, , vol. 38, p. 3397

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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