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CS-W001157 4
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3-Amino-5-chloropyridine

  • CAS No. 22353-34-0

  • Cat. No. CS-W003096
  • Purity≥98%
  • MDL No.MFCD03701386

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-chloropyridine|CS-W003096

Structure of 22353-34-0

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General Information

  • CAS No. 22353-34-0
  • Cat. No. CS-W003096
  • Purity ≥98%
  • MDL No. MFCD03701386
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight 128.56
  • Synonym(s) 5-Chloropyridin-3-amine
  • SMILES ClC1=CC(N)=CN=C1

Description

3-Amino-5-chloropyridine features a strategically positioned amino group flanked by a chlorine atom on the pyridine ring, enabling selective functionalization in synthetic routes. This electron-rich heterocycle integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions, offering enhanced reactivity without requiring stringent anhydrous handling.

Application

3-Amino-5-chloropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both the amino and chloro sites. The amino group facilitates nucleophilic substitution, while the ortho-chloro substituent supports palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing heterocyclic scaffolds and API intermediates in drug discovery workflows.

Synthesis

  • Route1
    • 3,5-Dichloropyridine Etoricoxib  Impurity|CS-0229442
      2457-47-8
    • ~%
    • In-stock
      3-Amino-5-chloropyridine|CS-W003096
      22353-34-0

    References

    • Roczniki Chemii, , vol. 18, p. 39,41 Chem. Zentralbl., , vol. 110, # I p. 1366
  • Route2

    References

    • Roczniki Chemii, , vol. 18, p. 210 Chem. Zentralbl., , vol. 110, # II p. 2779
  • Route3

    References

    • Roczniki Chemii, , vol. 18, p. 210 Chem. Zentralbl., , vol. 110, # II p. 2779

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.3172
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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