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trans-3-Methylcyclobutanamine hydrochloride

  • CAS No. 2231666-45-6

  • Cat. No. CS-0433455
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-3-Methylcyclobutanamine hydrochloride|CS-0433455

Structure of 2231666-45-6

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General Information

  • CAS No. 2231666-45-6
  • Cat. No. CS-0433455
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClN
  • Molecular Weight 121.61
  • Synonym(s) trans-3-methylcyclobutan-1-amine hydrochloride
  • SMILES N[C@H]1C[C@H](C)C1.[H]Cl

Description

trans-3-Methylcyclobutanamine hydrochloride offers a rigid, stereochemically defined amine scaffold ideal for probing conformational effects in medicinal chemistry. This bench-stable salt features enhanced solubility and predictable basicity, enabling seamless integration into peptide coupling, catalyst design, and target-oriented synthesis workflows.

Application

trans-3-Methylcyclobutanamine hydrochloride serves as a stable, bench-ready chiral building block for medicinal chemistry and asymmetric synthesis. Its constrained cyclobutane scaffold imparts conformational rigidity, enabling precise stereocontrol in target molecule design. The amine functionality facilitates straightforward derivatization via alkylation, acylation, or reductive amination, while the hydrochloride salt ensures excellent solubility and handling stability. Widely employed in the construction of bioactive heterocycles and API intermediates, it functions reliably in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.1654
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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