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trans-3-Methoxycyclobutanamine hydrochloride

  • CAS No. 1408074-49-6

  • Cat. No. CS-0045545
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-3-Methoxycyclobutanamine hydrochloride|CS-0045545

Structure of 1408074-49-6

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General Information

  • CAS No. 1408074-49-6
  • Cat. No. CS-0045545
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) RAC-(1R,3R)-3-METHOXYCYCLOBUTAN-1-AMINE HYDROCHLORIDE, TRANS
  • SMILES N[C@H]1C[C@H](OC)C1.[H]Cl

Description

trans-3-Methoxycyclobutanamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a rigid cyclobutane scaffold. The para-methoxy substituent enhances solubility and modulates electronic properties, while the protonated amine enables efficient salt formation. This configuration supports direct incorporation into peptide mimetics and bioactive molecule scaffolds under standard conditions.

Application

trans-3-Methoxycyclobutanamine hydrochloride serves as a valuable chiral building block in medicinal chemistry, offering a rigid, conformationally constrained scaffold. The amine functionality enables direct incorporation into bioactive molecules via standard coupling reactions, while the methoxy group provides moderate electron donation and enhanced solubility. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and straightforward purification—making it well-suited for high-throughput synthesis and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.5443
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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