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Structure of 22282-69-5
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2-Fluoropyridin-4-ol features a fluorine atom at the 2-position and a hydroxyl group at the 4-position on a pyridine ring, creating a polar, electron-deficient heterocycle. This arrangement enables direct functionalization at the 3- or 5-position, facilitating coupling reactions under mild conditions. The compound exhibits enhanced stability compared to analogous phenols and serves as a key building block in medicinal chemistry for kinase inhibitors and fluorescent probes.
2-Fluoropyridin-4-ol serves as a versatile building block for constructing fluorinated heterocycles and bioactive molecules. Its reactivity enables direct nucleophilic substitution at the C2 position, facilitating the synthesis of substituted pyridines under mild conditions. The hydroxyl group offers orthogonal handling for derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard synthetic workflows, it functions effectively in coupling reactions and scaffold elaboration for medicinal chemistry applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: