Lot numbers can be found on the outside label of a product:
6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
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CAS No. 220896-14-0
- Cat. No. CS-W009255
- Purity≥96%
- MDL No.MFCD11518940
*For research and further manufacturing use only, not for direct human use.
![6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one|CS-W009255](https://file.chemscene.com/productPIC/CS-W009255.gif)
Structure of 220896-14-0
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General Information
- CAS No. 220896-14-0
- Cat. No. CS-W009255
- Purity ≥96%
- MDL No. MFCD11518940
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅ClN₂O
- Molecular Weight 168.58
- Synonym(s) 6-Chloro-1H-pyrrolo[2,3-B]pyridin-2(3H)-one
- SMILES O=C1NC2=NC(Cl)=CC=C2C1
Description
6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 6-position and a lactam carbonyl group. This electron-deficient core integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and bioactive small molecules. The fused pyrrolopyridinone framework offers enhanced metabolic stability and favorable binding interactions in target-directed synthesis.
Application
6-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrrolopyridine scaffolds. Its chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the lactam functionality provides hydrogen bonding capacity and structural rigidity. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it well-suited for parallel synthesis campaigns and lead optimization workflows.
Synthesis
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Route1
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![3,3-Dibromo-6-chloro-1H-pyrrolo[2,3-b]pyridin-2-one|CS-0746459](https://file.chemscene.com/productPIC/CS-0746459.gif)
220896-12-8 -
295327-28-5 - ~%
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In-stock
220896-14-0
References
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US6369086 B1, ; US 6369086 B1
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Route2
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220896-12-8
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295327-28-5
- ~%
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![5-Bromo-6-chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one|CS-0004794](https://file.chemscene.com/productPIC/CS-0004794.gif)
297757-11-0 -
In-stock
220896-14-0
References
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US6350747 B1, ; Page column 70-71 ;
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Route3
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In-stock
55052-27-2 - ~%
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In-stock
220896-14-0
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5270 - 5273
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 41.99
- LogP 1.2296
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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